Infussion

Sterilization is a process designed to create a sterile condition. Traditionally sterile conditions is an absolute condition that is created as a result of the destruction and removal of all microorganisms living. This concept states that sterile is a relative term that has connotations, and the possibility of creating conditions of absolute freedom from microorganisms can only be suspected on the basis of the projected kinetic death rate of microbes.
(Lachman, p. 1254).
Large volume parenteral preparations are generally given by intravenous infusion to supplement body fluids, electrolytes, or to nourish. Intravenous infusion is a large volume parenteral preparations intended for intravenous administration. In general, intravenous infusion fluids used for replacement of body fluids and provide additional nutrients, to maintain the body's normal function inpatients who require adequate caloric intake during the healing period or after surgery. There are also other uses that as a carrier of other drugs.
Intravenous infusion fluids packaged in single dose form, in plastic or glass container, sterile, pyrogen free and free of other particles. Because of the large volume, preservatives are never used in intravenous infusion to avoid toxicity that may be caused by the preservative itself. Intravenous infusion fluids typically contain substances such as amino acids, dextrose, electrolytes and vitamins.
Although intravenous infusion fluid is a solution that isotonis desirable to minimize trauma to the blood vessels, but liquid and hipertonis hipotonis can be used. To minimize irritation of blood vessels, hipertonis solution is given in a slow speed.
Requirements
1. Appropriate content of the ingredients that are stated in the label and is in preparation; a reduction in effect during storage due to the destruction of chemical drugs.
2. Use a suitable container, which not only allows the preparations remained sterile but also prevent the occurrence of drug interactions with the container wall material.
3. United without any reaction. for it, some of the most determining factor is:
a) The germ-free
b) free of pyrogen
c) free of solvents that are not physiologically neutral
d) isotonis
e) isohidris
f) free float material
Advantages intravenous infusion is to produce drugs that work faster than other ways of giving and do not cause problems of drug absorption. While the loss of the drug given intravenously once through then the drug can not be removed from circulation as can be done for the drug when administered orally, such as ways to induce vomiting
Discussion:
Unnecessary infusion dosage volume pengawetkarena BESA. If the added preservatives, the amount of preservative is needed so that it can cause toxic effects.